US20260256851
2026-09-03
Human necessities
A61K35/742
The patent application introduces a novel carbonated beverage aimed at cognitive enhancement and gut-brain axis modulation. The beverage composition includes paraxanthine, Alpha-GPC, citicoline, taurine, and a carbonation-stable spore-forming probiotic, Bacillus coagulans GBI-30, 6086. These components work together to optimize cognitive functions through various pathways, including adenosinergic, cholinergic, GABAergic, and gut-brain axes. This composition is designed as a zero-sugar and zero-caffeine alternative to traditional energy drinks, providing a unique solution to the current market's reliance on caffeine-based products.
Paraxanthine, a primary metabolite of caffeine, serves as the main stimulant in this beverage. Unlike caffeine, paraxanthine offers a more predictable cognitive response due to its direct administration, bypassing the variability linked to caffeine metabolism. With a shorter half-life than caffeine, paraxanthine minimizes sleep disruption risks. Studies have shown that paraxanthine effectively enhances cognitive functions, outperforming caffeine in post-exercise scenarios. This beverage formulation includes 300 mg of paraxanthine, ensuring an effective dose for cognitive enhancement.
The beverage addresses the cholinergic gap in energy drinks by incorporating a dual choline precursor system. Alpha-GPC and citicoline are included to support acetylcholine synthesis and phosphatidylcholine membrane biosynthesis. These components help maintain cognitive performance under high demand by preventing choline substrate depletion. The formulation provides 300 mg of Alpha-GPC and 250 mg of citicoline per serving, optimized for oral bioavailability and effective cholinergic support.
Taurine is combined with paraxanthine to create a synergistic complex that enhances cognitive and performance benefits. Taurine's roles include GABAergic modulation, calcium homeostasis, osmoregulation, and anti-inflammatory neuroprotection. This combination ensures sustained alertness without the jittery effects often associated with stimulants. The beverage contains 1,000 mg of taurine, achieving an optimal taurine-to-paraxanthine ratio that balances stimulation and relaxation.
The inclusion of Bacillus coagulans GBI-30, 6086, a carbonation-stable probiotic, supports gut-brain axis modulation. This probiotic survives the acidic environment of carbonated beverages and germinates in the gastrointestinal tract. It contributes to cognitive clarity and mood regulation through the production of short-chain fatty acids, influencing serotonergic signaling and vagal activity. This component adds a unique dimension to the beverage's cognitive enhancement profile, differentiating it from other energy drinks.