US20260294793
2026-10-01
Human necessities
A61K9/0021
The dissolvable microneedle (DMN) system is a novel platform for delivering bioactive compounds through the skin or mucosal tissues. This system uses microneedles made from biocompatible, biodegradable materials that dissolve upon contact with interstitial or mucosal fluid. The DMN system can deliver a wide range of bioactive agents, including vitamins, peptides, proteins, and synthetic molecules, which may be encapsulated in nanocarriers like lipid nanoparticles and liposomes. This technology addresses issues such as poor bioavailability and patient compliance associated with traditional oral or injectable methods.
Traditional methods of delivering bioactive compounds, such as oral and parenteral routes, face significant challenges. Oral administration often leads to low bioavailability due to degradation in the gastrointestinal tract and first-pass metabolism. Parenteral routes are invasive, potentially painful, and require clinical oversight. The DMN system offers a minimally invasive alternative by creating microchannels in the skin or mucosal tissue for direct delivery of active ingredients. This system is adaptable for immediate, sustained, or biphasic release, supporting a broad spectrum of compounds that are unstable or poorly soluble.
The DMN system is versatile, supporting various delivery routes including transdermal, intradermal, and transmucosal applications. It is applicable in pharmaceutical, cosmetic, nutraceutical, veterinary, and agricultural fields. The system can be customized for different anatomical targets using various shapes and sizes of microneedles. This adaptability makes it suitable for treating nutrient deficiencies, metabolic disorders, skin care, wound healing, and more. Additionally, it offers agricultural applications for delivering bioactive compounds to plants.
The microneedles in the system are composed of materials like hyaluronic acid, chitosan, and alginate, which can be cross-linked for enhanced performance. They can incorporate stabilizing agents or excipients and are designed for controlled release. The microneedles can be configured in various forms such as face masks, patches, or wearable fabrics. They can also include embedded indicators to show the absorption status of the bioactive compounds. The system is designed to deliver compounds effectively, bypassing the limitations of conventional delivery methods.
The DMN system represents a scalable and biocompatible platform for delivering bioactive compounds across multiple sectors. It enhances bioavailability and patient compliance by offering a painless, self-administered option that can be tailored for a wide range of applications. This system is particularly beneficial for populations with difficulties in swallowing, malabsorption, or needle aversion, providing a promising solution for precision bioactive administration.